Case-control study of borderline ovarian tumors: reproductive history and exposure to exogenous female hormones.
نویسندگان
چکیده
Borderline ovarian tumors possess many of the same morphological features as their malignant counterparts, but they do not destructively invade the ovarian stroma, and the women in whom they develop generally have a favorable prognosis. Female residents of three urban counties of western Washington diagnosed with serous and mucinous borderline ovarian tumors between 1980 and 1985 (n = 116) were interviewed regarding past reproductive events. A random sample of women from the same counties (n = 158) was identified through random digit dialing and were interviewed. The risk of these ovarian tumors among women who had given birth to 1 or 2 children and to 3 or more children was, respectively, 0.7 and 0.4 that of nulliparous women. There was no consistent influence of increasing age at first live birth. Adjusting for parity, a history of lactation was associated with a 50% reduction in risk. Among nulliparous women, a further increase in risk was present in those who reported a history of infertility. Use of oral contraceptives was associated with a 60% reduction in risk. However, the size of the association was not dependent on duration, age at first use, or years since last usage. In conclusion, borderline tumors appear to have similar epidemiological patterns with regard to reproductive events as their more malignant counterparts.
منابع مشابه
Effects of Carthamus tinctorius L. on the ovarian histomorphology and the female reproductive hormones in mice
Objective: Carthamus tinctorius L. (Safflower) is a member of the asteraceae family which had been classified as a fertility regulator in the traditional medicine. The purpose of this study was to investigate its possible effects on the ovarian histomorphology and the levels of female reproductive hormones in the mice. Materials and Methods: Sixty adult female Balb/C mice were selected and rand...
متن کاملRelationship between Melasma, ovarian cysts and androgenic hormones: A case-control study
Background: Melasma is the acquired, gradual and symmetric hyper pigmentation of the face. Melasma has been related to many factors such as pregnancy, genetic, endocrine and sun exposure but the exact relationship to endocrine factors isn’t still clear. Objectives: To evaluate the relationship between melasma and polycystic ovarian disease and androgenic hormones. Patients and Methods: Th...
متن کاملتومور بوردرلاین موسینوس تخمدان هم‌زمان با آدنوکارسینومای سرویکس در یک بیمار: گزارش موردی
Background: Ovarian mucinous borderline tumors are divided into two morphologic groups: endocervical-like and intestinal type. Most endocervical adenocarcinomas exhibit mucinous and/or endometrioid differentiation, they infrequently metastasize to the ovaries but may simulate primary ovarian tumors (both atypical proliferative or borderline and carcinoma). In patients with mucinous adenocarcino...
متن کاملRisk Factors of Breast Cancer in Kuwait: Case-Control Study
Background: Breast cancer incidence has increased rapidly inKuwait, but there haven’t been any studies investigating the recognized risk factors of breast cancer inKuwait. The aim of the study was to investigate breast cancer risk factors among women inKuwait. Methods: A case-control study was conducted in Kuwait from May 2003 to March 2004 using a questionnaire including socio-demographic data...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cancer research
دوره 48 20 شماره
صفحات -
تاریخ انتشار 1988